Biochem/physiol Actions

Reversible: yes

Product does not compete with ATP.

Primary Targetcaspase-8

Cell permeable: yes

General description

Potent, cell-permeable and reversible inhibitor of caspase-8 and Granzyme B.

A potent, cell-permeable, and reversible inhibitor of caspase-8 and Granzyme B. The N-terminal sequence (amino acids 1-16) corresponds to the hydrophobic region of the signal peptide of Kaposi fibroblast growth factor and confers cell permeability to the peptide.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.Hamada, E., et al. 1990. J. Hepatol. 30, 807.

Packaging

1 mg in Plastic ampoule

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Sequence

Ac-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Ile-Glu-Thr-Asp-CHO

Warning

Toxicity: Standard Handling (A)